2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness.
Identifieur interne : 000315 ( Main/Exploration ); précédent : 000314; suivant : 0003162019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness.
Auteurs : Robyn Ralph [Canada] ; Jocelyne Lew [Canada] ; Tiansheng Zeng [République populaire de Chine] ; Magie Francis [Canada] ; Bei Xue [République populaire de Chine] ; Melissa Roux [Canada] ; Ali Toloue Ostadgavahi [Canada] ; Salvatore Rubino [Italie] ; Nicholas J. Dawe [Canada] ; Mohammed N. Al-Ahdal [Arabie saoudite] ; David J. Kelvin [République populaire de Chine] ; Christopher D. Richardson [Canada] ; Jason Kindrachuk [Canada] ; Darryl Falzarano [Canada] ; Alyson Anne Kelvin [Canada]Source :
- Journal of infection in developing countries [ 1972-2680 ] ; 2020.
Descripteurs français
- KwdFr :
- Analyse de séquence de protéine, Animaux, Humains, Infections à coronavirus (), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Pandémies, Pneumopathie virale (transmission), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Protéines virales (), Protéines virales (génétique), Réservoirs d'agents pathogènes (médecine vétérinaire), Réservoirs d'agents pathogènes (virologie), Transmission de maladie infectieuse, Vaccination, Vaccins antiviraux, Voyage, Zoonoses.
- MESH :
- génétique : Protéines virales.
- médecine vétérinaire : Réservoirs d'agents pathogènes.
- virologie : Infections à coronavirus, Pneumopathie virale, Réservoirs d'agents pathogènes.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Analyse de séquence de protéine, Animaux, Humains, Infections à coronavirus, Pandémies, Protéines virales, Transmission de maladie infectieuse, Vaccination, Vaccins antiviraux, Voyage, Zoonoses.
English descriptors
- KwdEn :
- Animals, Betacoronavirus (genetics), Coronavirus Infections (epidemiology), Coronavirus Infections (prevention & control), Coronavirus Infections (transmission), Coronavirus Infections (virology), Disease Reservoirs (veterinary), Disease Reservoirs (virology), Disease Transmission, Infectious, Humans, Pandemics, Pneumonia, Viral (epidemiology), Pneumonia, Viral (transmission), Pneumonia, Viral (virology), Sequence Analysis, Protein, Travel, Vaccination, Viral Proteins (chemistry), Viral Proteins (genetics), Viral Vaccines, Zoonoses.
- MESH :
- chemical , chemistry : Viral Proteins.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus, Viral Proteins.
- prevention & control : Coronavirus Infections.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- veterinary : Disease Reservoirs.
- virology : Coronavirus Infections, Disease Reservoirs, Pneumonia, Viral.
- Animals, Disease Transmission, Infectious, Humans, Pandemics, Sequence Analysis, Protein, Travel, Vaccination, Viral Vaccines, Zoonoses.
Abstract
On 31 December 2019 the Wuhan Health Commission reported a cluster of atypical pneumonia cases that was linked to a wet market in the city of Wuhan, China. The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. As of 28 January 2020, there are in excess of 4,500 laboratory-confirmed cases, with > 100 known deaths. As with the SARS-CoV, infections in children appear to be rare. Travel-related cases have been confirmed in multiple countries and regions outside mainland China including Germany, France, Thailand, Japan, South Korea, Vietnam, Canada, and the United States, as well as Hong Kong and Taiwan. Domestically in China, the virus has also been noted in several cities and provinces with cases in all but one provinence. While zoonotic transmission appears to be the original source of infections, the most alarming development is that human-to-human transmission is now prevelant. Of particular concern is that many healthcare workers have been infected in the current epidemic. There are several critical clinical questions that need to be resolved, including how efficient is human-to-human transmission? What is the animal reservoir? Is there an intermediate animal reservoir? Do the vaccines generated to the SARS-CoV or MERS-CoV or their proteins offer protection against 2019-nCoV? We offer a research perspective on the next steps for the generation of vaccines. We also present data on the use of in silico docking in gaining insight into 2019-nCoV Spike-receptor binding to aid in therapeutic development. Diagnostic PCR protocols can be found at https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus.
DOI: 10.3855/jidc.12425
PubMed: 32088679
Affiliations:
- Arabie saoudite, Canada, Italie, République populaire de Chine
- Manitoba
- Winnipeg
- Université du Manitoba
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000224
- to stream PubMed, to step Curation: 000224
- to stream PubMed, to step Checkpoint: 000323
- to stream Ncbi, to step Merge: 002545
- to stream Ncbi, to step Curation: 002545
- to stream Ncbi, to step Checkpoint: 002545
- to stream Main, to step Merge: 000318
- to stream Main, to step Curation: 000315
Le document en format XML
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Dawe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. nc350339@dal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N" last="Al-Ahdal">Mohammed N. Al-Ahdal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. profahdal@gmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J" last="Kelvin">David J. Kelvin</name><affiliation wicri:level="1"><nlm:affiliation>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China. dkelvin@jidc.org.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, Christopher D" sort="Richardson, Christopher D" uniqKey="Richardson C" first="Christopher D" last="Richardson">Christopher D. 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International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan, Canada. darryl.falzarano@usask.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, Alyson Anne" sort="Kelvin, Alyson Anne" uniqKey="Kelvin A" first="Alyson Anne" last="Kelvin">Alyson Anne Kelvin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. akelvin@jidc.org.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32088679</idno><idno type="pmid">32088679</idno><idno type="doi">10.3855/jidc.12425</idno><idno type="wicri:Area/PubMed/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000224</idno><idno type="wicri:Area/PubMed/Curation">000224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000224</idno><idno type="wicri:Area/PubMed/Checkpoint">000323</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000323</idno><idno type="wicri:Area/Ncbi/Merge">002545</idno><idno type="wicri:Area/Ncbi/Curation">002545</idno><idno type="wicri:Area/Ncbi/Checkpoint">002545</idno><idno type="wicri:Area/Main/Merge">000318</idno><idno type="wicri:Area/Main/Curation">000315</idno><idno type="wicri:Area/Main/Exploration">000315</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness.</title><author><name sortKey="Ralph, Robyn" sort="Ralph, Robyn" uniqKey="Ralph R" first="Robyn" last="Ralph">Robyn Ralph</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan, Canada. robyn.ralph@usask.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Lew, Jocelyne" sort="Lew, Jocelyne" uniqKey="Lew J" first="Jocelyne" last="Lew">Jocelyne Lew</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan, Canada. jocelyne.lew@usask.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Tiansheng" sort="Zeng, Tiansheng" uniqKey="Zeng T" first="Tiansheng" last="Zeng">Tiansheng Zeng</name><affiliation wicri:level="1"><nlm:affiliation>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China. allenzengts@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Francis, Magie" sort="Francis, Magie" uniqKey="Francis M" first="Magie" last="Francis">Magie Francis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. m.francis@dal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Xue, Bei" sort="Xue, Bei" uniqKey="Xue B" first="Bei" last="Xue">Bei Xue</name><affiliation wicri:level="1"><nlm:affiliation>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China. bz520251@dal.ca.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Roux, Melissa" sort="Roux, Melissa" uniqKey="Roux M" first="Melissa" last="Roux">Melissa Roux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. melissa.rioux@dal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Toloue Ostadgavahi, Ali" sort="Toloue Ostadgavahi, Ali" uniqKey="Toloue Ostadgavahi A" first="Ali" last="Toloue Ostadgavahi">Ali Toloue Ostadgavahi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Ali.Toloue@dal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Rubino, Salvatore" sort="Rubino, Salvatore" uniqKey="Rubino S" first="Salvatore" last="Rubino">Salvatore Rubino</name><affiliation wicri:level="1"><nlm:affiliation>Sezione di Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy. rubino@uniss.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sezione di Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Dawe, Nicholas J" sort="Dawe, Nicholas J" uniqKey="Dawe N" first="Nicholas J" last="Dawe">Nicholas J. Dawe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. nc350339@dal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N" last="Al-Ahdal">Mohammed N. Al-Ahdal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. profahdal@gmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J" last="Kelvin">David J. Kelvin</name><affiliation wicri:level="1"><nlm:affiliation>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China. dkelvin@jidc.org.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, Christopher D" sort="Richardson, Christopher D" uniqKey="Richardson C" first="Christopher D" last="Richardson">Christopher D. Richardson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. chris.richardson@dal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. kjk1642@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><affiliation wicri:level="1"><nlm:affiliation>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan, Canada. darryl.falzarano@usask.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, Alyson Anne" sort="Kelvin, Alyson Anne" uniqKey="Kelvin A" first="Alyson Anne" last="Kelvin">Alyson Anne Kelvin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. akelvin@jidc.org.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of infection in developing countries</title><idno type="eISSN">1972-2680</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Betacoronavirus (genetics)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Disease Reservoirs (veterinary)</term><term>Disease Reservoirs (virology)</term><term>Disease Transmission, Infectious</term><term>Humans</term><term>Pandemics</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (transmission)</term><term>Pneumonia, Viral (virology)</term><term>Sequence Analysis, Protein</term><term>Travel</term><term>Vaccination</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Vaccines</term><term>Zoonoses</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Animaux</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Pandémies</term><term>Pneumopathie virale (transmission)</term><term>Pneumopathie virale (virologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Réservoirs d'agents pathogènes (médecine vétérinaire)</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Transmission de maladie infectieuse</term><term>Vaccination</term><term>Vaccins antiviraux</term><term>Voyage</term><term>Zoonoses</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Réservoirs d'agents pathogènes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Reservoirs</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Réservoirs d'agents pathogènes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Disease Reservoirs</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Transmission, Infectious</term><term>Humans</term><term>Pandemics</term><term>Sequence Analysis, Protein</term><term>Travel</term><term>Vaccination</term><term>Viral Vaccines</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Animaux</term><term>Humains</term><term>Infections à coronavirus</term><term>Pandémies</term><term>Protéines virales</term><term>Transmission de maladie infectieuse</term><term>Vaccination</term><term>Vaccins antiviraux</term><term>Voyage</term><term>Zoonoses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">On 31 December 2019 the Wuhan Health Commission reported a cluster of atypical pneumonia cases that was linked to a wet market in the city of Wuhan, China. The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. As of 28 January 2020, there are in excess of 4,500 laboratory-confirmed cases, with > 100 known deaths. As with the SARS-CoV, infections in children appear to be rare. Travel-related cases have been confirmed in multiple countries and regions outside mainland China including Germany, France, Thailand, Japan, South Korea, Vietnam, Canada, and the United States, as well as Hong Kong and Taiwan. Domestically in China, the virus has also been noted in several cities and provinces with cases in all but one provinence. While zoonotic transmission appears to be the original source of infections, the most alarming development is that human-to-human transmission is now prevelant. Of particular concern is that many healthcare workers have been infected in the current epidemic. There are several critical clinical questions that need to be resolved, including how efficient is human-to-human transmission? What is the animal reservoir? Is there an intermediate animal reservoir? Do the vaccines generated to the SARS-CoV or MERS-CoV or their proteins offer protection against 2019-nCoV? We offer a research perspective on the next steps for the generation of vaccines. We also present data on the use of in silico docking in gaining insight into 2019-nCoV Spike-receptor binding to aid in therapeutic development. Diagnostic PCR protocols can be found at https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Canada</li><li>Italie</li><li>République populaire de Chine</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Ralph, Robyn" sort="Ralph, Robyn" uniqKey="Ralph R" first="Robyn" last="Ralph">Robyn Ralph</name></noRegion><name sortKey="Dawe, Nicholas J" sort="Dawe, Nicholas J" uniqKey="Dawe N" first="Nicholas J" last="Dawe">Nicholas J. Dawe</name><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><name sortKey="Francis, Magie" sort="Francis, Magie" uniqKey="Francis M" first="Magie" last="Francis">Magie Francis</name><name sortKey="Kelvin, Alyson Anne" sort="Kelvin, Alyson Anne" uniqKey="Kelvin A" first="Alyson Anne" last="Kelvin">Alyson Anne Kelvin</name><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name><name sortKey="Lew, Jocelyne" sort="Lew, Jocelyne" uniqKey="Lew J" first="Jocelyne" last="Lew">Jocelyne Lew</name><name sortKey="Richardson, Christopher D" sort="Richardson, Christopher D" uniqKey="Richardson C" first="Christopher D" last="Richardson">Christopher D. Richardson</name><name sortKey="Roux, Melissa" sort="Roux, Melissa" uniqKey="Roux M" first="Melissa" last="Roux">Melissa Roux</name><name sortKey="Toloue Ostadgavahi, Ali" sort="Toloue Ostadgavahi, Ali" uniqKey="Toloue Ostadgavahi A" first="Ali" last="Toloue Ostadgavahi">Ali Toloue Ostadgavahi</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Tiansheng" sort="Zeng, Tiansheng" uniqKey="Zeng T" first="Tiansheng" last="Zeng">Tiansheng Zeng</name></noRegion><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J" last="Kelvin">David J. Kelvin</name><name sortKey="Xue, Bei" sort="Xue, Bei" uniqKey="Xue B" first="Bei" last="Xue">Bei Xue</name></country><country name="Italie"><noRegion><name sortKey="Rubino, Salvatore" sort="Rubino, Salvatore" uniqKey="Rubino S" first="Salvatore" last="Rubino">Salvatore Rubino</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Al Ahdal, Mohammed N" sort="Al Ahdal, Mohammed N" uniqKey="Al Ahdal M" first="Mohammed N" last="Al-Ahdal">Mohammed N. Al-Ahdal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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